Incorporating Prior Knowledge about Genetic Variants into the Analysis of Genetic Association Data: An Empirical Bayes Approach.

Abstract excerpt

In a genome-wide association study (GWAS), the probability that a single nucleotide polymorphism (SNP) is not associated with a disease is its local false discovery rate (LFDR). The LFDR for each SNP is relative to a reference class of SNPs. For example, the LFDR of an exonic SNP can vary widely depending on whether it is considered relative to the separate reference class of other exonic SNPs or relative to the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bayes Theorem
• Share to Computational Biology