Article
Microvessel density in muscles of dogs with golden retriever muscular dystrophy.
Neuromuscular disorders : NMD - 1 Feb 2005
Nguyen Frédérique, Guigand Lydie, Goubault-Leroux Isabelle, Wyers Monique, Cherel Yan
Abstract excerpt
Due to the abundance of muscle, intravascular administration seems required for efficient gene or cell therapy of muscular dystrophy. Here, we examined the skeletal muscle microvasculature to assess if it is altered with dystrophin deficiency. Image analysis of capillaries was performed in three muscles of one- to ten-month-old golden retriever muscular dystrophy (GRMD) dogs and compared with healthy controls. In...
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