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Article

An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain.

Development (Cambridge, England) - 1 Sept 2010

Poitras Luc, Yu Man, Lesage-Pelletier Cindy, Macdonald Ryan B, Gagné Jean-Philippe, Hatch Gary, Kelly Isabelle, Hamilton Steven P, Rubenstein John L R, Poirier Guy G, Ekker Marc

Abstract excerpt

Dlx homeobox genes play a crucial role in the migration and differentiation of the subpallial precursor cells that give rise to various subtypes of gamma-aminobutyric acid (GABA)-expressing neurons of the forebrain, including local-circuit cortical interneurons. Aberrant development of GABAergic interneurons has been linked to several neurodevelopmental disorders, including epilepsy, schizophrenia, Rett syndrome...

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Share to Cell Movement
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Enhancer Elements, Genetic

Share to Gene Expression Regulation, Developmental

Share to Homeodomain Proteins

Share to Prosencephalon

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Source

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Identifiers

PMID: 20702565
DOI: 10.1242/dev.051052
PMCID: PMC3188590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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