Article
Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.
Archives of neurology - 1 Aug 2010
Nishioka Kenya, Wider Christian, Vilariño-Güell Carles, Soto-Ortolaza Alexandra I, Lincoln Sarah J, Kachergus Jennifer M, Jasinska-Myga Barbara, Ross Owen A, Rajput Alex, Robinson Christopher A, Ferman Tanis J, Wszolek Zbigniew K, Dickson Dennis W, Farrer Matthew J
Abstract excerpt
OBJECTIVE: To determine the association of the genes that encode alpha-, beta-, and gamma-synuclein (SNCA, SNCB, and SNCG, respectively) with diffuse Lewy body disease (DLBD). DESIGN: Case-control study. Subjects A total of 172 patients with DLBD consistent with a clinical diagnosis of Parkinson disease dementia/dementia with Lewy bodies and 350 clinically and 97 pathologically normal controls. INTERVENTIONS:...
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