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Article

Neuropathology in genetic Parkinson's disease: a focused review of pathological and clinical findings.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2026

Barbosa Pedro Melo, Parmera Jacy Bezerra, Warner Thomas T

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder with a complex interaction between genetic and environmental causal factors. The role of Lewy body (LB) pathology (Lewy bodies and neurites) in genetic PD remains unclear, as some gene mutations do not consistently present with alpha-synuclein aggregates or LB in postmortem studies. This review aims to evaluate neuropathological data from genetic PD cases,...

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PMID: 41428076
DOI: 10.1007/s00702-025-03088-7

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SNCA

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