Article
Beta-synuclein gene alterations in dementia with Lewy bodies.
Neurology - 14 Sept 2004
Ohtake H, Limprasert P, Fan Y, Onodera O, Kakita A, Takahashi H, Bonner L T, Tsuang D W, Murray I V J, Lee V M-Y, Trojanowski J Q, Ishikawa A, Idezuka J, Murata M, Toda T, Bird T D, Leverenz J B, Tsuji S, La Spada A R
Abstract excerpt
OBJECTIVE: To determine whether mutations in the genes for alpha-synuclein or beta-synuclein are responsible for dementia with Lewy bodies (DLB), a disorder closely related to Parkinson disease (PD). METHODS: The authors ascertained 33 sporadic cases of DLB and 10 kindreds segregating DLB. DNA samples from the 43 index cases were screened for alterations in the genes for alpha-synuclein and beta-synuclein, as...
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