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Article

DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma.

American journal of physiology. Gastrointestinal and liver physiology - 1 May 2011

Sodhi Chhinder, Levy Ryan, Gill Roop, Neal Matthew D, Richardson Ward, Branca Maria, Russo Anthony, Prindle Thomas, Billiar Timothy R, Hackam David J

Abstract excerpt

Intestinal mucosal injury occurs after remote trauma although the mechanisms that sense remote injury and lead to intestinal epithelial disruption remain incompletely understood. We now hypothesize that Toll-like receptor 4 (TLR4) signaling on enterocytes after remote injury, potentially through the endogenous TLR4 ligand high-mobility group box-1 (HMGB1), could lead to intestinal dysfunction and bacterial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21233273
DOI: 10.1152/ajpgi.00373.2010
PMCID: PMC3094143

Genes

TLR4
HMGB1
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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