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Article

The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes.

Biochemical and biophysical research communications - 3 Sept 2010

Sudarshan Sawali R, Schlegel Richard, Liu Xuefeng

Abstract excerpt

The HPV-16 E5 protein resides in membranes of the endoplasmic reticulum (ER) and modulates cell growth and viral replication. In order to help define its biological activities, we analyzed E5-induced changes in human keratinocyte gene expression. Our studies identified the downregulation of spliced XBP-1 transcripts, a key player in the ER stress response, as a biochemical marker of E5 expression. IRE1alpha, the...

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Source

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Identifiers

PMID: 20688044
DOI: 10.1016/j.bbrc.2010.07.125
PMCID: PMC2934880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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