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Article

E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I

25 Aug 2004

Abstract excerpt

Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium. It is localized to the Golgi apparatus (GA) and endoplasmic reticulum. The E5 protein of bovine papillomavirus (BPV) impairs the synthesis and stability of major histocompatibility (MHC) class I complexes and...

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Identifiers

PMID: 15386416
DOI: 10.1002/ijc.20558

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E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class IPMID 15386416Read ↗

E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain <i>via</i> its first hydrophobic domainSemantic proximity Read ↗

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All 4 di-leucine motifs in the first hydrophobic domain of the E5 oncoprotein of human papillomavirus type 16 are essential for surface MHC class I downregulation activity and E5 endomembrane localization.Semantic proximity Read ↗

The E5 protein of the human papillomavirus type 16 down-regulates HLA-I surface expression in calnexin-expressing but not in calnexin-deficient cellsSemantic proximity Read ↗

The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes.Semantic proximity Read ↗

The E5 protein of human papillomavirus type 16 perturbs MHC class II antigen maturation in human foreskin keratinocytes treated with interferon-γSemantic proximity Read ↗

Human Papillomavirus 16 E5 Inhibits Interferon Signaling and Supports Episomal Viral MaintenanceSemantic proximity Read ↗

High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon ExpressionSemantic proximity Read ↗

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The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming proteinSemantic proximity Read ↗

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