Article
Reduced tumorigenicity and drug resistance through the downregulation of octamer-binding protein 4 and Nanog transcriptional factor expression in human breast stem cells.
Molecular medicine reports - 1 Mar 2015
Huang Zheng-Jie, You Jun, Luo Wei-Yuan, Chen Bai-Sheng, Feng Qing-Zhao, Wu Bing-Lin, Jiang Long, Luo Qi
Abstract excerpt
Breast cancer is the most common type of malignancy among females. Previous studies examining breast cancer tissue have demonstrated the presence of stem cells, and have detected octamer‑binding protein 4 (Oct4) and Nanog transcription factor expression. In the present study, breast cancer stem cells (CSCs) were isolated and enriched from MDA‑MB‑231 breast cancer cell lines, and were defined as MDA‑MB‑231 stem...
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