Article
Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele.
Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2010
O'Byrne Michelle R, Au Kit Sing, Morrison Alanna C, Lin Jone-Ing, Fletcher Jack M, Ostermaier Kathryn K, Tyerman Gayle H, Doebel Sabine, Northrup Hope
Abstract excerpt
BACKGROUND: Meningomyelocele (MM) results from lack of closure of the neural tube during embryologic development. Periconceptional folic acid supplementation is a modifier of MM risk in humans, leading toan interest in the folate transport genes as potential candidates for association to MM. METHODS: This study used the SNPlex Genotyping (ABI, Foster City, CA) platform to genotype 20 single polymorphic variants...
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