Article
Association of retinoic acid receptor genes with meningomyelocele.
Birth defects research. Part A, Clinical and molecular teratology - 1 Jan 2011
Tran Phong X, Au Kit Sing, Morrison Alanna C, Fletcher Jack M, Ostermaier Kathryn K, Tyerman Gayle H, Northrup Hope
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs) occur in as many as 0.5-2 per 1000 live births in the United States. One of the most common and severe neural tube defects is meningomyelocele (MM) resulting from failed closure of the caudal end of the neural tube. MM has been induced by retinoic acid teratogenicity in rodent models. We hypothesized that genetic variants influencing retinoic acid (RA) induction via retinoic...
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