Article
Retinoic acid and alpha-difluoromethylornithine induce different expression of neural-specific cell adhesion molecules in differentiating neuroblastoma cells.
Progress in clinical and biological research - 1 Jan 1991
Melino G, Piacentini M, Patel K, Annicchiarico-Petruzzelli M, Piredda L, Kemshead J T
Abstract excerpt
Human neuroblastoma cells SK-N-BE(2) can be induced to differentiate towards a neuronal phenotype by retinoic acid (RA) or a schwannian/glial phenotype by alpha-difluoromethylornithine (DFMO), producing differential binding of 14 antibodies (MAbs). RA induced the expression of the neural cell adh...
Topics
- Antibodies, Monoclonal
- Blotting, Northern
- Blotting, Western
- Cell Adhesion Molecules, Neuronal
- Cell Differentiation
- Cell Line
- Eflornithine
- Fluorescent Antibody Technique
- Gene Expression
- Humans
- Models, Neurological
- Molecular Weight
- Neuroblastoma
- Neurons
- Phenotype
- Tretinoin