Article
DR-nm23 expression affects neuroblastoma cell differentiation, integrin expression, and adhesion characteristics.
Medical and pediatric oncology - 1 Jan 2001
Amendola R, Martinez R, Negroni A, Venturelli D, Tanno B, Calabretta B, Raschellà G
Abstract excerpt
BACKGROUND AND PROCEDURE: Nm23 gene family has been associated with metastasis suppression and differentiation. We studied DR-nm23 during neuroblastoma cells differentiation. DR-nm23 expression increased after retinoic acid induction of differentiation in human cell lines SK-N-SH and LAN-5. RESULTS: In several cell lines, overexpression of DR-nm23 was associated with more differentiated phenotypes. SK-N-SH cells...
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