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Article

Confounding from cryptic relatedness in haplotype-based association studies.

Genetica - 1 Oct 2010

Zhang Feng, Deng Hong-Wen

Abstract excerpt

Cryptic relatedness was suggested to be an important source of confounding in population-based association studies (PBAS). The impact of cryptic relatedness on the performance of haplotype phase inference and haplotype-based association tests is not clear. In this study, we used the Hapmap genetic data to simulate a set of related samples. We evaluated the accuracy of haplotype phase inferred by PHASE 2.1 and...

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Share to Computer Simulation
Share to Confounding Factors, Epidemiologic
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Models, Genetic

Share to Models, Statistical

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 20680405
DOI: 10.1007/s10709-010-9476-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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