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Article

Identifying cryptic relationships.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Sun Lei, Dimitromanolakis Apostolos

Abstract excerpt

Cryptic relationships such as first-degree relatives often appear in studies that collect population samples such as the case-control genome-wide association studies (GWAS). Cryptic relatedness not only creates increased type 1 error rate but also affects other aspects of GWAS, such as population stratification via principal component analysis. Here we discuss two effective methods, as implemented in PREST and...

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PMID: 22307693
DOI: 10.1007/978-1-61779-555-8_4

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