The KRAS-variant is associated with risk of developing double primary breast and ovarian cancer.

doi:10.1371/journal.pone.0037891

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Article

The KRAS-variant is associated with risk of developing double primary breast and ovarian cancer.

PloS one - 1 Jan 2012

Pilarski Robert, Patel Divya A, Weitzel Jeffrey, McVeigh Terri, Dorairaj Jemima J, Heneghan Helen M, Miller Nicola, Weidhaas Joanne B, Kerin Michael J, McKenna Megan, Wu Xifeng, Hildebrandt Michelle, Zelterman Daniel, Sand Sharon, Shulman Lee P

Abstract excerpt

PURPOSE: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian cancer risk in patients from hereditary breast and ovarian families (HBOC), and with the risk of premenopausal triple negative breast cancer, we evaluated the association of the KRAS-variant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22662244
DOI: 10.1371/journal.pone.0037891
PMCID: PMC3360659

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The KRAS-variant is associated with risk of developing double primary breast and ovarian cancer.PMID 22662244Read ↗

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