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Article

KIF1Bβ suppresses hepatocellular carcinoma by transporting and secreting FBLN5 to attenuate the integrin pathway.

Gut - 7 Apr 2026

Gao Chengming, Wang Yahui, Zhou Guangming, Shi Peipei, Wang Ji-Ao, Wu Junjie, Liao Song, Yan Han, Qiu Yifei, Yan Hongbo, Zeng Tao, Li Ruofan, Zhang Ying, Cao Pengbo, Yang Chenning, Ye Jiazhou, Liang Rong, Wang Yuting, Cheng Furong, Hao Kaina, Zhang Jinwen, Hu Xiaoyu, Guo Rui, Wang Qiming, He Fuchu, Li Yuanfeng, Zhou Gangqiao

Abstract excerpt

BACKGROUND: Our previous genome-wide association study (GWAS) identified that chromosome 1p36.22 locus contributes to the risk of hepatocellular carcinoma (HCC). OBJECTIVE: We aimed to identify the functional causative variant(s) and target gene(s) at this locus. DESIGN: Two independent HCC case-control populations, totally consisting of 1934 cases and 1446 controls, were used to validate the association between...

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Share to Carcinoma, Hepatocellular
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Integrins

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Source

Identifiers

PMID: 41087058
DOI: 10.1136/gutjnl-2025-336230

Genes

FBLN5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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