Article
Cardiac conduction is required to preserve cardiac chamber morphology.
Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2010
Chi Neil C, Bussen Markus, Brand-Arzamendi Koroboshka, Ding Chunhua, Olgin Jeffrey E, Shaw Robin M, Martin Gail R, Stainier Didier Y R
Abstract excerpt
Electrical cardiac forces have been previously hypothesized to play a significant role in cardiac morphogenesis and remodeling. In response to electrical forces, cultured cardiomyocytes rearrange their cytoskeletal structure and modify their gene expression profile. To translate such in vitro dat...
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