Article
Intracardiac flow dynamics regulate atrioventricular valve morphogenesis.
Cardiovascular research - 1 Oct 2014
Kalogirou Stamatia, Malissovas Nikos, Moro Enrico, Argenton Francesco, Stainier Didier Y R, Beis Dimitris
Abstract excerpt
AIMS: Valvular heart disease is responsible for considerable morbidity and mortality. Cardiac valves develop as the heart contracts, and they function throughout the lifetime of the organism to prevent retrograde blood flow. Their precise morphogenesis is crucial for cardiac function. Zebrafish is an ideal model to investigate cardiac valve development as it allows these studies to be carried out in vivo through...
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