Article

Developmental outflow tract abnormalities of Jag1-deficient mice are associated with abnormal ventricular activation and desynchronized contraction

2025-08-12

Abstract excerpt

The Notch signaling pathway is an evolutionarily conserved intercellular communication mechanism essential for mammalian embryonic development. Mutations in the human Jagged1 ( Jag1 ) gene, which encodes a ligand of the Notch receptor, cause Alagille syndrome—an autosomal dominant disorder frequently associated with congenital heart diseases (CHDs) such as Tetralogy of Fallot. To investigate the role of Jag1 i...

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Literature Corpus work: b295f9f2-8b6c-55b5-87de-b52973dfc534
DOI: 10.1101/2025.08.08.669322

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