Dominant lethal cell mutants detected by the autoradiographic assay for exotoxin A resistance.

doi:10.1016/0027-5107(91)90148-h

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Dominant lethal cell mutants detected by the autoradiographic assay for exotoxin A resistance.

Mutation research - 1 Jul 1991

Tiah M, Ronen A

Abstract excerpt

The autoradiographic assay (AR assay) for P. aeruginosa exotoxin A (PE) resistance in cultured mouse fibroblasts detects mutants able to synthesize proteins in the presence of the toxin, presumably due to mutations in the structural gene for elongation factor 2 (EF-2). Detection by the AR assay of PER cells is independent of their ability to divide. The frequencies of both spontaneous and mutagen-induced PER...

Topics

ADP Ribose Transferases
Animals
Autoradiography
Bacterial Toxins
Cell Division
Cell Survival
Cells, Cultured
Ethyl Methanesulfonate
Eukaryotic Initiation Factor-2
Exotoxins
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes

Genes, Dominant

Genes, Lethal

Mice

Mutagens

Mutation

Phenotype

Source

Open in PubMed

Identifiers

PMID: 2067534
DOI: 10.1016/0027-5107(91)90148-h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2067534-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Dominant lethal cell mutants detected by the autoradiographic assay for exotoxin A resistance.PMID 2067534Read ↗

An in situ protocol for measuring the expression of chemically-induced mutations in mammalian cells.Semantic proximity Read ↗

Arrest of embryo development in Brassica napus mediated by modified Pseudomonas aeruginosa exotoxin A.Semantic proximity Read ↗

lacZ mouse embryonic fibroblasts detect both clastogens and mutagens.Semantic proximity Read ↗

Resistance to Pseudomonas toxin A: a sensitive marker to screen for mutagenic substances using V79 cells.Semantic proximity Read ↗

Effects of differential expression of the 49-kilodalton exoenzyme S by Pseudomonas aeruginosa on cultured eukaryotic cells.Semantic proximity Read ↗

Analysis of in vivo mutation in the hprt and tk genes of mouse lymphocytes.Semantic proximity Read ↗

Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes.Semantic proximity Read ↗

Selection of Pseudomonas exotoxin-resistant cells with altered expression of alpha 2MR/LRP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.