Article
Dominant lethal cell mutants detected by the autoradiographic assay for exotoxin A resistance.
Mutation research - 1 Jul 1991
Tiah M, Ronen A
Abstract excerpt
The autoradiographic assay (AR assay) for P. aeruginosa exotoxin A (PE) resistance in cultured mouse fibroblasts detects mutants able to synthesize proteins in the presence of the toxin, presumably due to mutations in the structural gene for elongation factor 2 (EF-2). Detection by the AR assay of PER cells is independent of their ability to divide. The frequencies of both spontaneous and mutagen-induced PER...
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