Article
Association of IKBA gene polymorphisms with the development of asthma.
Human immunology - 1 Nov 2010
Park Se-Min, Chang Hun-Soo, Rhim Taiyoun, Park Sung Woo, Jang An Soo, Park Jong Sook, Uh Soo-Taek, Na Ju Ock, Hwang Hun-Gyu, Kim Yong Hoon, Lee Mi Young, Chung Il Yup, Park Byung Lae, Shin Hyung Doo, Park Choon-Sik
Abstract excerpt
Nuclear factor-κB (NF-κB) orchestrates the expression of genes responsible for airway inflammation and remodeling in asthma. The activity of NF-κB is tightly regulated by IKBA, which may be modulated by genetic polymorphisms of the IKBA gene. We investigated the association between asthma susceptibility and IKBA gene polymorphisms in a Korean population. Genotyping was performed in BA (bronchial asthma) and NC...
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