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Article

A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction: the t(8;22)(q24.13;q11.21).

American journal of human genetics - 13 Aug 2010

Sheridan Molly B, Kato Takema, Haldeman-Englert Chad, Jalali G Reza, Milunsky Jeff M, Zou Ying, Klaes Ruediger, Gimelli Georgio, Gimelli Stefania, Gemmill Robert M, Drabkin Harry A, Hacker April M, Brown Julia, Tomkins David, Shaikh Tamim H, Kurahashi Hiroki, Zackai Elaine H, Emanuel Beverly S

Abstract excerpt

Palindrome-mediated genomic instability has been associated with chromosomal translocations, including the recurrent t(11;22)(q23;q11). We report a syndrome characterized by extremity anomalies, mild dysmorphia, and intellectual impairment caused by 3:1 meiotic segregation of a previously unrecognized recurrent palindrome-mediated rearrangement, the t(8;22)(q24.13;q11.21). There are at least ten prior reports of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20673865
DOI: 10.1016/j.ajhg.2010.07.002
PMCID: PMC2917714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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