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Article

The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements

8 Apr 2010

Abstract excerpt

The constitutional t(11;22)(q23;q11) is the most common recurrent non-Robertsonian translocation in humans. The breakpoint sequences of both chromosomes are characterized by several hundred base pairs of palindromic AT-rich repeats (PATRRs). Similar PATRRs have also been identified at the breakpoints of other nonrecurrent translocations, suggesting that PATRR-mediated chromosomal translocation represents one of...

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PMID: 20507342
DOI: 10.1111/j.1399-0004.2010.01445.x

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