Article
Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Dec 2011
Di Paolo Daniela, Ambrogio Chiara, Pastorino Fabio, Brignole Chiara, Martinengo Cinzia, Carosio Roberta, Loi Monica, Pagnan Gabriella, Emionite Laura, Cilli Michele, Ribatti Domenico, Allen Theresa M, Chiarle Roberto, Ponzoni Mirco, Perri Patrizia
Abstract excerpt
The anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is involved in the pathogenesis of different types of human cancers, including neuroblastoma (NB). In NB, ALK overexpression, or point mutations, are associated with poor prognosis and advanced stage disease. Inhibition of ALK kinase activity by small-molecule inhibitors in lung cancers carrying ALK translocations has shown therapeutic...
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