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Article

The IFIH1/MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early- vs. Late-Onset Skin Disease and Increases the Risk of Arthritis in a Spanish Cohort of Psoriasis.

International journal of molecular sciences - 30 Sept 2023

Coto-Segura Pablo, Vázquez-Coto Daniel, Velázquez-Cuervo Lucinda, García-Lago Claudia, Coto Eliecer, Queiro Rubén

Abstract excerpt

The melanoma differentiation-associated protein 5 (MDA5; encoded by the IFIH1 gene) mediates the activation of the interferon pathway in response to a viral infection. This protein is also upregulated in autoimmune diseases and psoriasis skin lesions. IFIH1 gene variants that increase MDA5 activity have been associated with an increased risk for immune-mediated diseases, including psoriasis. Our aim is to...

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Share to Arthritis, Psoriatic
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-Induced Helicase, IFIH1

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 37834254
DOI: 10.3390/ijms241914803
PMCID: PMC10572774

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The IFIH1/MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early- vs. Late-Onset Skin Disease and Increases the Risk of Arthritis in a Spanish Cohort of Psoriasis.PMID 37834254Read ↗

The IFIH1/MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early Versus Late-Onset Skin Disease and Increased the Risk of Arthritis in a Spanish Cohort of Psoriatic DiseaseSemantic proximity Read ↗

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The interferon-induced helicase C domain-containing protein 1 gene variant (rs1990760) as an autoimmune-based pathology susceptibility factor.Semantic proximity Read ↗

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