Article
A rare coding allele in IFIH1 is protective for psoriatic arthritis.
Annals of the rheumatic diseases - 1 Jul 2017
Budu-Aggrey Ashley, Bowes John, Stuart Philip E, Zawistowski Matthew, Tsoi Lam C, Nair Rajan, Jadon Deepak Rohit, McHugh Neil, Korendowych Eleanor, Elder James T, Barton Anne, Raychaudhuri Soumya
Abstract excerpt
OBJECTIVES: Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. While many common risk alleles have been reported for association with PsA as well as psoriasis, few rare coding alleles have yet been identified. METHODS: To identify rare coding variation associated with PsA risk or protection, we genotyped 41 267 variants with the exome chip and investigated association within an...
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