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Inhibition of zygotic DNA repair: transcriptome analysis of the offspring in trout ( <i>Oncorhynchus mykiss</i> )

28 Nov 2014

Abstract excerpt

Zygotic repair of the paternal genome is a key event after fertilization. Spermatozoa accumulate DNA strand breaks during spermatogenesis and can suffer additional damage by different factors, including cryopreservation. Fertilization with DNA-damaged spermatozoa (DDS) is considered to promote implantation failures and abortions, but also long-term effects on the progeny that could be related with a defective...

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PMID: 25433028
DOI: 10.1530/rep-14-0382

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