Article
Characterization of T cell maturity in thymic epithelial cell tumors from BUF/Mna spontaneous thymoma rats and BUF/Mna-Rnu/+ rats showing delayed thymomagenesis.
International journal of clinical and experimental pathology - 30 Jun 2010
Inoue Masayoshi, Matsuyama Mutsushi, Shiono Hiroyuki, Honda Osamu, Sumikawa Hiromitsu, Tomiyama Noriyuki, Okumura Meinoshin
Abstract excerpt
BUF/Mna rats develop thymomas spontaneously, which histologically mimic human thymomas. Although neoplasms in this rat strain contain a large number of immature lymphocytes, the phenotype has not been sufficiently assessed. We characterized T cell phenotypes in tumors from BUF/Mna rats in the present study. We also analyzed BUF/Mna-Rnu/+ rats, a heterozygous strain with suppressive thymomagenesis, and compared...
Topics
- Animals
- Animals, Congenic
- Antigens, CD
- Cell Separation
- Disease Models, Animal
- Epithelial Cells
- Flow Cytometry
- Humans
- Phenotype
- Rats
- T-Lymphocytes
- Thymoma
- Thymus Gland