Article
Increased thymocyte CD4+CD8+ cells and T-cell receptor beta gene rearrangements in thymoma.
The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi - 1 Oct 2003
Sakuraba Motoki, Motoji Toshiko, Nitta Sumio, Mizoguchi Hideaki, Ohnuki Takamasa
Abstract excerpt
Epithelial cells in thymoma and thymic carcinoma may influence T-cell development in the tumor. In this study, we investigated the cell surface phenotype and T-cell receptor (TCR) gene rearrangement of thymocytes in thymic tumors. TCR rearrangement was observed in all cases of thymoma (A, AB, B1-2). A faint band in each digestion suggested the deletion between D1 to C1 or D1 to J2, and an additional rearrangement...
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