Functional full-term placentas formed from parthenogenetic embryos using serial nuclear transfer

Abstract excerpt

Mammalian parthenogenetic embryos invariably die in mid-gestation from imprinted gene defects and placental hypoplasia. Based on chimera experiments, trophoblastic proliferation is supposed to be inhibited in the absence of a male genome. Here, we show that parthenogenetic mouse embryonic cell nuclei can be reprogrammed by serial rounds of nuclear transfer without using any genetic modification. The durations of...

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• Share to Epigenetics and DNA Methylation
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