Article
Cardiomyogenic induction of human mesenchymal stem cells by altered Rho family GTPase expression on dendrimer-immobilized surface with D-glucose display.
Biomaterials - 1 Oct 2010
Kim Mee-Hae, Kino-oka Masahiro, Maruyama Nao, Saito Atsuhiro, Sawa Yoshiki, Taya Masahito
Abstract excerpt
The commitment of stem cells to different lineages is regulated by many cues in the intercellular signals from the microenvironment system. In the present study, we found that alterations in Rho family GTPase activities derived from cytoskeletal formation can lead to guidance of cardiomyogenic differentiation of human mesenchymal stem cells (hMSCs) during in vitro culture. To regulate the cytoskeletal formation...
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