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Article

Nanogrooved substrate promotes direct lineage reprogramming of fibroblasts to functional induced dopaminergic neurons.

Biomaterials - 1 Mar 2015

Yoo Junsang, Noh Myungkyung, Kim Hongnam, Jeon Noo Li, Kim Byung-Soo, Kim Jongpil

Abstract excerpt

The generation of dopaminergic (DA) neurons via direct lineage reprogramming can potentially provide a novel therapeutic platform for the study and treatment of Parkinson's disease. Here, we showed that nanoscale biophysical stimulation can promote the direct lineage reprogramming of somatic fibroblasts to induced DA (iDA) neurons. Fibroblasts that were cultured on flat, microgrooved, and nanogrooved substrates...

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Identifiers

PMID: 25662493
DOI: 10.1016/j.biomaterials.2014.12.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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