Article
A genetic strategy for combined screening and localized imaging of breast cancer.
Molecular imaging and biology - 1 Jun 2011
Warram Jason M, Borovjagin Anton V, Zinn Kurt R
Abstract excerpt
PURPOSE: Improvements are needed for the early detection of breast cancer, as current imaging methods lack sensitivity to detect small tumors and assess their disease phenotype. PROCEDURES: To address this issue, the dual reporter adenoviral vector (Ad5/3-Id1-SEAP-Id1-mCherry) was produced with a cancer-specific Id1 promoter driving expression of a blood-based screening reporter (secreted embryonic alkaline...
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