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Article

Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice.

PloS one - 29 Mar 2011

Goldman Scott J, Chen Elizabeth, Taylor Robert, Zhang Sheng, Petrosky Whitney, Reiss Michael, Jin Shengkan

Abstract excerpt

BACKGROUND: In humans, imaging of tumors provides rapid, accurate assessment of tumor growth and location. In laboratory animals, however, the imaging of spontaneously occurring tumors continues to pose many technical and logistical problems. Recently a mouse model was generated in which a chimeric protein consisting of HIF-1α oxygen-dependent degradation domain (ODD) fused to luciferase was ubiquitously...

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Identifiers

PMID: 21479246
DOI: 10.1371/journal.pone.0018269
PMCID: PMC3066234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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