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Article

Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development.

Cancer letters - 10 May 2013

Ruan Qing, Xi Lei, Boye Sanford L, Han Song, Chen Zhi J, Hauswirth William W, Lewin Alfed S, Boulton Michael E, Law Brian K, Jiang Wen G, Jiang Huabei, Cai Jun

Abstract excerpt

We aimed to develop an anti-angiogenic model for breast cancer by combining (1) siRNA-based therapy delivered by self-complementary adeno-associated virus serotype 2 (scAAV2) vectors to target tumor vasculature, and (2) noninvasive monitoring to tumor response to anti-angiogenesis by photoacoustic (PA) imaging. scAAV2 vector containing 7 surface exposed tyrosine to phenylanine capsid mutations was able to...

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Identifiers

PMID: 23196055
DOI: 10.1016/j.canlet.2012.11.016
PMCID: PMC4094357

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ATF6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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