Article
Fibroblast growth factor induces a neural stem cell phenotype in foetal forebrain progenitors and during embryonic stem cell differentiation.
Molecular and cellular neurosciences - 1 Jul 2008
Pollard Steven M, Wallbank Richard, Tomlinson Simon, Grotewold Lars, Smith Austin
Abstract excerpt
Neural stem (NS) cell lines may be derived via differentiation of pluripotent embryonic stem (ES) cells or from foetal forebrain. However, because NS cells arise in vitro from heterogeneous populations their immediate cellular origin remains unclear. We used microarray-based expression profiling to identify a set of markers expressed by mouse NS cells but not ES cells. One differentially expressed gene encodes...
Topics
- Animals
- Cell Differentiation
- Cell Line
- Cells, Cultured
- Embryonic Stem Cells
- Female
- Fibroblast Growth Factors
- Genetic Markers
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Neurons
- Phenotype
- Pregnancy
- Prosencephalon