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Article

Advantages and considerations in the confirmation of mitochondrial DNA mutations by denaturing HPLC and pyrosequencing.

Annals of the New York Academy of Sciences - 1 Jul 2010

Yen Hsiu-Chuan, Hsu Wei-Chien, Lin Chih-Lung, Chen Guang-Wu, Huang Yu-Hsiang

Abstract excerpt

Human mitochondrial DNA (mtDNA) encodes 13 polypeptides essential for oxidative phosphorylation. Because of the unique features of "replicative segregation" and "threshold expression" of mtDNA genetics, identification of homoplasmy versus heteroplasmy status is critical. Results from various detection methods may lead to different interpretations on formation or outcome of mtDNA mutations, such as the conclusion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20649533
DOI: 10.1111/j.1749-6632.2010.05626.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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