Article
Searching for a needle in the haystack: comparing six methods to evaluate heteroplasmy in difficult sequence context.
Biotechnology advances - 1 Jan 2000
Kurelac Ivana, Lang Martin, Zuntini Roberta, Calabrese Claudia, Simone Domenico, Vicario Saverio, Santamaria Monica, Attimonelli Marcella, Romeo Giovanni, Gasparre Giuseppe
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations have been involved in disease, aging and cancer and furthermore exploited for evolutionary and forensic investigation. When investigating mtDNA mutations the peculiar aspects of mitochondrial genetics, such as heteroplasmy and threshold effect, require suitable approaches which must be sensitive enough to detect low-level heteroplasmy and, precise enough to quantify the exact...
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