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Article

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

Blood - 6 Oct 2011

Jankowska Anna M, Makishima Hideki, Tiu Ramon V, Szpurka Hadrian, Huang Yun, Traina Fabiola, Visconte Valeria, Sugimoto Yuka, Prince Courtney, O'Keefe Christine, Hsi Eric D, List Alan, Sekeres Mikkael A, Rao Anjana, McDevitt Michael A, Maciejewski Jaroslaw P

Abstract excerpt

Chronic myelomonocytic leukemia (CMML), a myelodysplastic/myeloproliferative neoplasm, is characterized by monocytic proliferation, dysplasia, and progression to acute myeloid leukemia. CMML has been associated with somatic mutations in diverse recently identified genes. We analyzed 72 well-characterized patients with CMML (N = 52) and CMML-derived acute myeloid leukemia (N = 20) for recurrent chromosomal...

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methyltransferase 3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer of Zeste Homolog 2 Protein

Share to Gene Expression Regulation, Leukemic

Share to Histone Demethylases

Share to Leukemia, Myelomonocytic, Chronic

Share to Polycomb Repressive Complex 2

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Source

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Identifiers

PMID: 21828135
DOI: 10.1182/blood-2010-10-311019
PMCID: PMC3193268

Genes

ASXL1
CBL
IDH1
JAK2
KRAS
NRAS
TET2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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