Article
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.
Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2010
Leonard Effendi, Ajikumar Parayil Kumaran, Thayer Kelly, Xiao Wen-Hai, Mo Jeffrey D, Tidor Bruce, Stephanopoulos Gregory, Prather Kristala L J
Abstract excerpt
A common strategy of metabolic engineering is to increase the endogenous supply of precursor metabolites to improve pathway productivity. The ability to further enhance heterologous production of a desired compound may be limited by the inherent capacity of the imported pathway to accommodate high precursor supply. Here, we present engineered diterpenoid biosynthesis as a case where insufficient downstream...
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