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Article

Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli.

Applied and environmental microbiology - 1 Jun 2007

Leonard Effendi, Lim Kok-Hong, Saw Phan-Nee, Koffas Mattheos A G

Abstract excerpt

The identification of optimal genotypes that result in improved production of recombinant metabolites remains an engineering conundrum. In the present work, various strategies to reengineer central metabolism in Escherichia coli were explored for robust synthesis of flavanones, the common precursors of plant flavonoid secondary metabolites. Augmentation of the intracellular malonyl coenzyme A (malonyl-CoA) pool...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17468269
DOI: 10.1128/AEM.00200-07
PMCID: PMC1932724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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