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Article

The role of RNA processing in the pathogenesis of motor neuron degeneration

1 Jul 2010

Abstract excerpt

Motor neurons are large, highly polarised cells with very long axons and a requirement for precise spatial and temporal gene expression. Neurodegenerative disorders characterised by selective motor neuron vulnerability include various forms of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). A rapid expansion in knowledge on the pathophysiology of motor neuron degeneration has occurred in...

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PMID: 20642879
DOI: 10.1017/s1462399410001523

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