Article

SMN controls neuromuscular junction integrity through U7 snRNP

2021-09-01

Abstract excerpt

The neuromuscular junction (NMJ) is an essential synapse for animal survival whose loss is a key hallmark of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). While insights into the function of the causative genes implicate RNA dysregulation in NMJ pathogenesis, the RNA-mediated mechanisms controlling the biology of this specialized synapse that go awry in d...

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Literature Corpus work: 1fc75c0a-de12-5f8a-a853-9f90f73a394f
DOI: 10.1101/2021.08.31.458410

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