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Article

Inducible Gene and shRNA Expression in Resident Hematopoietic Stem Cells In Vivo

16 Jul 2010

Abstract excerpt

Hematopoietic stem cells (HSC) are probably the best understood somatic stem cells and often serve as a paradigm for other stem cells. Nevertheless, most current techniques to genetically manipulate them in vivo are either constitutive and/or induced in settings of hematopoietic stress such as after irradiation. Here, we present a conditional expression system that allows for externally controllable transgenesis...

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PMID: 20641037
DOI: 10.1002/stem.460

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