Article
Computational characterization for catalytic activities of human CD38's wild type, E226 and E146 mutants.
Interdisciplinary sciences, computational life sciences - 1 Jun 2010
Nguyen My H, Dang Van U, Luu Boi V
Abstract excerpt
A series of the complexes of human CD38's wild type, E226 and E146 mutants as well have been simulated. The biosoftwares well simulate the penetration of nicotinamide-adenine-dinucleotide (NAD) into the active site. The nicotinamide end of NAD penetrates deep into the active site consistent with cleavage of the nicotinamide-glycosidic bond which is the first step of catalysis creating a Michaelis complex regarded...
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