A molecular model for the active site of S-adenosyl-L-homocysteine hydrolase.

doi:10.1007/BF00124340

Back to search

Article

A molecular model for the active site of S-adenosyl-L-homocysteine hydrolase.

Journal of computer-aided molecular design - 1 Jun 1991

Yeh J C, Borchardt R T, Vedani A

Abstract excerpt

S-adenosyl-L-homocysteine hydrolase (AdoHcy hydrolase, EC 3.3.1.1), a specific target for antiviral drug design, catalyzes the hydrolysis of AdoHcy to adenosine (Ado) and homocysteine (Hcy) as well as the synthesis of AdoHcy from Ado and Hcy. The enzyme isolated from different sources has been sh...

Topics

Adenosylhomocysteinase
Amino Acid Sequence
Animals
Binding Sites
Hydrolases
Kinetics
L-Lactate Dehydrogenase
Models, Molecular
Molecular Sequence Data
Mutation
NAD
Protein Conformation
Rats
Software

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.