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Article

A molecular model for the active site of S-adenosyl-L-homocysteine hydrolase.

Journal of computer-aided molecular design - 1 Jun 1991

Yeh J C, Borchardt R T, Vedani A

Abstract excerpt

S-adenosyl-L-homocysteine hydrolase (AdoHcy hydrolase, EC 3.3.1.1), a specific target for antiviral drug design, catalyzes the hydrolysis of AdoHcy to adenosine (Ado) and homocysteine (Hcy) as well as the synthesis of AdoHcy from Ado and Hcy. The enzyme isolated from different sources has been shown to contain tightly bound NAD+. Based on the 2.0 A-resolution X-ray crystal structure of dogfish lactate...

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PMID: 1919618
DOI: 10.1007/BF00124340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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