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Article

Investigating effect of mutation on structure and function of G6PD enzyme: a comparative molecular dynamics simulation study.

PeerJ - 1 Jan 2022

Rani Sadaf, Malik Fouzia Perveen, Anwar Jamshed, Zafar Paracha Rehan

Abstract excerpt

Several natural mutants of the human G6PD enzyme exist and have been reported. Because the enzymatic activities of many mutants are different from that of the wildtype, the genetic polymorphism of G6PD plays an important role in the synthesis of nucleic acids via ribulose-5-phosphate and formation of reduced NADP in response to oxidative stress. G6PD mutations leading to its deficiency result in the neonatal...

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Identifiers

PMID: 35368337
DOI: 10.7717/peerj.12984
PMCID: PMC8973466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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