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Article

Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase.

Scientific reports - 18 Jan 2018

Ribeiro João Meireles, Canales José, Cabezas Alicia, Rodrigues Joaquim Rui, Pinto Rosa María, López-Villamizar Iralis, Costas María Jesús, Cameselle José Carlos

Abstract excerpt

Cyclic ADP-ribose (cADPR) is a messenger for Ca2+ mobilization. Its turnover is believed to occur by glycohydrolysis to ADP-ribose. However, ADP-ribose/CDP-alcohol diphosphatase (ADPRibase-Mn) acts as cADPR phosphohydrolase with much lower efficiency than on its major substrates. Recently, we showed that mutagenesis of human ADPRibase-Mn at Phe37, Leu196 and Cys253 alters its specificity: the best substrate of...

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PMID: 29348648
DOI: 10.1038/s41598-017-18393-9
PMCID: PMC5773619

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